Published April 2017

The goal of this practice guideline is to examine evidence for the SUDEP incidence rate in epilepsy populations and for prognostic factors for SUDEP occurrence. This in turn will inform an honest and balanced discussion when clinicians counsel people about SUDEP, and provide insight into areas where

Published April 2015

This practice guideline considers the evidence for prognosis and treatment to provide evidence-based recommendations for treatment of adults with an unprovoked first seizure. Reaffirmed on February 10, 2024. Codeveloped with the American Epilepsy Society. Endorsed by the American Neurological Ass

Published March 2003

This article addresses published evidence on the safety and efficacy of localized resective surgery, either temporal or neocortical, as treatment for uncontrolled complex partial seizures. Reaffirmed on July 16, 2022.

Published May 1999

The purpose of this advisory is to: 1) Determine the current role of felbamate for treatment of various types of epilepsy; 2) Provide guidelines to ensure maximum safety and effectiveness when the risk/benefit ratio is in favor of the use of felbamate.   Reaffirmed on April 30, 2022.

Published June 2018

This is an update to the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs). This update reviews new evidence for efficacy, safety, and tolerability of CLB, VGB, and the 8 second-generat

Published January 2003

This practice parameter reviews the current evidence about treatment with AED after a child experiences a first unprovoked seizure. Reaffirmed on July 12, 2024.

Published September 2000

For this practice parameter, the authors reviewed available evidence on evaluation of the first nonfebrile seizure in children in order to make practice recommendations based on this available evidence. Last reaffirmed on October 21, 2023.

Published July 2009

We reassessed the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including the risk of pregnancy complications or other medical problems during pregnancy in WWE compared to other women, change in seizure frequency, the risk of status epilepticus, an

Published December 2021

This practice advisory update reviews the risks and benefits of discontinuing antiseizure medication use in seizure-free patients. According to the practice advisory, people with epilepsy who have been seizure-free (two years for adults and 1.5 to two years for children/adolescents) and stop use of

Published January 2017

The goal of this practice guideline is to review available evidence and provide practitioners with evidence-based recommendations for the role of fMRI in epilepsy surgery evaluation and postsurgical outcome prediction. Reaffirmed on February 25, 2023. Endorsed by the American College of Radiology

Published November 2006

This Practice Parameter reviews available evidence concerning the value of diagnostic testing in children and adolescents with SE and provides recommendations based upon this evidence. Treatment guidelines are not included but are under development. Reaffirmed on January 22, 2022.

Published January 2012

The objective of this guideline is to develop guidelines for selection of antiepileptic drugs (AEDs) among people with HIV/AIDS. Reaffirmed on February 10, 2024. Endorsed by the American Epilepsy Society.

Published July 2009

We reassessed the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid use, prenatal vitamin K use, risk of hemorrhagic disease of the newborn, clinical implications of placental and breast milk transfer of antiepilept

Published June 2018

Since the 2004 publications, the US Food and Drug Administration (FDA) approved 6 new third-generation AEDs and 2 older AEDs. This update reviews new evidence for efficacy of these AEDs in managing treatment-resistant (TR) focal epilepsies and generalized epilepsies (GEs) in children and adults. Re

Published August 2013

The objective of this guideline is to evaluate the evidence since the 1999 assessment regarding efficacy and safety of vagus nerve stimulation (VNS) for epilepsy, currently approved as adjunctive therapy for partial-onset seizures in patients >12 years. Reaffirmed on July 16, 2022. Endorsed by the

Published October 2007

This reassessment is aimed at analyzing the usefulness of neuroimaging as a screening procedure for altering management of the emergency patient presenting with a seizure, and at determining which clinical and historical characteristics indicate the need for a neuroimaging study for such patients.

Published September 2005

Based on the evidence classification scheme of the American Academy of Neurology (AAN), we propose recommendations for the use of serum PRL assay to differentiate ES from psychogenic NES. We also reviewed the usefulness of serum PRL in other settings, such as following syncope and repetitive seizure

Published May 2024

This practice guideline provides updated evidence-based conclusions and recommendations regarding the effects of antiseizure medications and folic acid supplementation on the prevalence of major congenital malformations, adverse perinatal outcomes, and neurodevelopmental outcomes in children born to